Detection of Epidermal Growth Factor Receptor Variations by Partially Denaturing HPLC
نویسندگان
چکیده
منابع مشابه
Detection of epidermal growth factor receptor variations by partially denaturing HPLC.
BACKGROUND Epidermal growth factor receptor gene (EGFR) variants may be useful markers for identifying responders to gefitinib and erlotinib, small-molecule tyrosine kinase inhibitors of EGFR; therefore, sensitive and cost-effective assays are needed to detect EGFR variants in routine clinical samples. We have developed a partially denaturing HPLC (pDHPLC) assay that is superior to direct seque...
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ژورنال
عنوان ژورنال: Clinical Chemistry
سال: 2007
ISSN: 0009-9147,1530-8561
DOI: 10.1373/clinchem.2006.074831